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Graduate School of Biomedical and Health Sciences, Hiroshima University

論文・著書Academic Paper

2024 2023 2022 2021 2020 2019 2018 2017

2024

学術論文

  1. Oguro A, Kaga Y, Sato H, Fujiyama T, Fujimoto S, Nagai S, Matsuyama M, Miyara M, Ishihara Y, Yamazaki T, Imaoka S, and Kotake Y, Mice deficient in the phosphatase activity of sEH showed decreased levels of 2-AG in the olfactory bulbs and depressive-like behavior. FEBS Letters, 598(24):2980-2994, 2024(Editor's choice)
  2. Tamura A, Siswanto FM, Yoshimura T, Oguro A, Imaoka S, Hydrogen peroxide induces ethanol-inducible CYP2E1 via the NFkB-classical pathway: CYP2E1 mRNA levels are not high in alcoholic hepatitis. Current Drug Metabolism 25(5):307-316, 2024

  3. Tamura A, Kitayama K, Adachi M, Hashimoto K, Oguro A, Imaoka S, Prolyl hydroxylase domain enzyme(isoform 1-3, PHD1-3), but not factor-inhibiting HIF-1 (FIH-1), interact with the IKK complex and attenuate LPS-activated NF-kB, J. Toxicol. Sci., In Press


2023

学術論文

  1. Hatano M, Hatamiya S, Miyara M, Kotake Y. Tributyltin activates the Keap1-Nrf2 pathway via a macroautophagy-independent reduction in Keap1. J. Toxicol. Sci., 48(3), 161-168, 2023
  2. Ohtsuki Y, Sanoh S, Yamao M, Kojima Y, Kotake Y, Tateno C. Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver. J. Toxicol. Sci., 48(2), 99-108, 2023
  3. Ishida K, Takeda K, Takehara Y, Takabayashi T, Miyara M, Sanoh S, Kawai H, Ohta S, Kotake Y. Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons. Biol Pharm Bull. 46(2), 292-300, 2023
  4. Imamiya R, Shinohara A, Yakura D, Yamaguchi T, Ueda K, Oguro A, Minamiyama Y, Ichikawa H, Horiguchi Y, Osada-Oka M. Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes. mBio. 2023 Feb 28;14(1):e0305122.
  5. Tanaka M, Okuda T, Itoh K, Ishihara N, Oguro A, Fujii-Kuriyama Y, Nabetani Y, Yamamoto M, Vogel CFA, Ishihara Y. Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation. Part Fibre Toxicol. 2023 Feb 16;20(1):6.
  6. Siswanto FM, Okukawa K, Tamura A, Oguro A, and Imaoka S, Hydrogen peroxide activates APE1/Ref-1 via NF-κB and Parkin: A role in liver cancer resistance to oxidative stress. Free Radic Res. 3;1-16. doi: 10.1080/10715762.2023.2229509, 2023
  7. Oguro A, Fujiyama T, Ishihara Y, Kataoka C, Yamamoto M, Eto K, Komohara Y, Imaoka S, Sakuragi T, Tsuji M, Shibata E, Kotake Y, and Yamazaki T, Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder. J. Lipid Res. 64(11):100458, 2023 doi: 10.1016/j.jlr.2023.100458
  8. Siswanto FM, Firmasyah RD, Handayani MDN, Oguro A, Imaoka S, Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9). Curr Drug Metab. 2023　 Volume 24, Issue 9
  9. Kawabata K, Muraoka H, Miyara M, Kotake Y, Nishi H, Photodegradation profiling of nitrendipine: evaluation of active pharmaceutical ingredient, tablets and its altered forms.Anal Sci. 2023 Nov;39(11):1791-1803. doi: 10.1007/s44211-023-00400-x. Epub 2023 Aug 4. PMID: 37540327
  10. Kawabata K, Sakaue M, Akimoto S, Miyara M, Kotake Y, Nishi H, Evaluation of photostability of azelnidipine tablets and structure determination of its photoproducts.J Pharm Biomed Anal. 2023 Sep 5;233:115471. doi: 10.1016/j.jpba.2023.115471. Epub 2023 May 24. PMID: 37245328

2022

学術論文

  1. Imado E, Sun S, Abawa AR, Tahara T, Kochi T, Huynh TNB, Asano S, Hasebe S, Nakamura Y, Hisaoka-Nakashima K, Kotake Y, Irifune M, Tsuga K, Takuma K, Morioka N, Kiguchi N, Ago Y. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation. Neurochem Int. 2022 Aug 24;160:105415.
  2. Mizutare T, Sanoh S, Kanazu T, Ohta S, Kotake Y. Improved predictability of hepatic clearance with optimal pH for acyl-glucuronidation in liver microsomes. J. Pharm. Sci. 2022 Aug 19:S0022-3549(22)00350-1.
  3. Umeda-Miyara K, Miyara M, Sanoh S, Kotake Y. Trehalose decreases mRNA and protein expressions of c-Jun and JunB in human cervical cancer HeLa cells. J. Biochem. 172(3), 177-187, 2022
  4. Takaoka N, Sanoh S, Ohta S, Esmaeeli M, Leimkühler S, Kurosaki M, Terao M, Garattini E, Kotake Y. Involvement of aldehyde oxidase in the metabolism of aromatic and aliphatic aldehyde-odorants in the mouse olfactory epithelium. Arch. Biochem. Biophys. 715, 109099, 2022
  5. Hatamiya S, Miyara M, Kotake Y. Tributyltin inhibits autophagy by decreasing lysosomal acidity in SH-SY5Y cells. Biochem. Biophys. Res. Commun. 592, 31-37, 2022
  6. Sato K, Sanoh S, Ishida Y, Tateno C, Ohta S, Kotake Y. Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays. J. Toxicol. Sci. 47(7), 277-288, 2022
  7. Yoshida K, Doi Y, Iwazaki N, Yasuhara H, Ikenaga Y, Shimizu H, Nakada T, Watanabe T, Tateno C, Sanoh S, Kotake Y. Prediction of human pharmacokinetics for low-clearance compounds using pharmacokinetic data from chimeric mice with humanized livers. Clin. Transl. Sci. 15(1), 79-91, 2022
  8. Ishihara N, Okuda T, Hagino H, Oguro A, Tani Y, Okochi H, Tokoro C, Fujii-Kuriyama Y, Itoh K, Vogel CFA, Ishihara Y. Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter. J. Toxicol. Sci., 47(5), 201-210, 2022
  9. Ihara K, Oguro A, Imaishi H, Diagnosis of Parkinson's disease by investigating the inhibitory effect of serum components on P450 inhibition assay. Sci. Rep. 12(1):6622, 2022
  10. Siswanto FM, Sakuma R, Oguro A, Imaoka S, Chlorogenic acid activates Nrf2/SKN-1 and prolongs the lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 pathway and activation of DAF16f. J Gerontol A Biol Sci Med Sci. 2022
  11. Siswanto FM, Mitsuoka Y, Nakamura M, Oguro A, Imaoka S, Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia. Sci. Rep. 12:21265, 2022

著書・その他

  • 大黒 亜美「JSTnews 2022年10月号 さきがける科学人インタビュ―」掲載
  • 大黒 亜美「ファルマシア11月号 トピックスG環境・衛生」

2021

学術論文

  1. Motonaga M, Watanabe H, Tayama Y, Shimizu R, Sanoh S, Kotake Y, Kitamura S, Ohta S, Sugihara K. Comparison of the components of three types of miso (fermented soybean paste) by 1H NMR metabolomic analysis. BPB Reports, 4(5), 148-154, 2021.
  2. Takeda N, Nakamura Y, Ikeda K, Takaoka N, Hisaoka-Nakashima K, Sanoh S, Kotake Y, Nakata Y, Morioka N. Treatment with histone deacetylase inhibitor attenuates peripheral inflammation-induced cognitive dysfunction and microglial activation: The effect of SAHA as a peripheral HDAC Inhibitor. Neurochem. Res., 46(9), 2285-2296, 2021.
  3. Yabuki A., Miyara M., Umeda-Miyara K., Takao S., Sanoh S., Kotake Y. MiT/TFE family members supress L-leucyl-L-leucine methyl ester-induced cell death. J. Toxicol. Sci., 46(3), 143-156, 2021.
  4. Klionsky DJ., ....., Kotake Y., ..... et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy, 17(1), 1-382, 2021.

著書・その他

  • 高岡 尚輝「優秀口頭発表賞を受賞して」日本薬物動態学会ニュースレター, 36(1), 2021.

2020

学術論文

  1. Sanoh S., Hanada H., Kashiwagi K., Mori T., Goto-Inoue N., Suzuki KT., Mori J., Nakamura N., Yamamoto T., Kitamura S., Kotake Y., Sugihara K., Ohta S., Kashiwagi A. Amiodarone bioconcentration and supprresion of metamorphosis in Xenopus. Aquat. Toxicol., 228, 105623, 2020.
  2. Sanoh S., Naritomi Y., Kitamura S., Shinagawa A., Masakazu K., Tateno C., Ohta S. Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptyde (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism. Xenobiotica. 50(11), 1370-1379, 2020.
  3. Kidoguchi N., Ishida K., Sanoh S., Miyara M., Kotake Y. Triphenyltin inhibits GA-binding protein α nuclear translocation. Fundam. Toxicol. Sci.,7(1), 33-40, 2020.

著書・その他

  • 佐能 正剛「肝再生における臓器連関による薬物代謝能の変化を考慮した個別化薬物治療にむけて」細胞, 52(7), 26-27, 2020.
  • 佐能 正剛「奨励賞を受賞して」日本薬物動態学会ニュースレター, 35(1), 2020.

2019

学術論文

  1. Fujino C., Watanabe Y., Sanoh S., Hattori S., Nakajima H., Uramaru N., Kojima H., Yoshinari K., Ohta S., Kitamura S. Comparative study of the effect of 17 parabens on PXR-, CAR, and PPARα-mediated transcriptional activation (2019). Food Chem. Toxicol., 133, 110792.
  2. Ishida C., Sanoh S., Kotake Y. CYP1A2 down-regulation by obeticholic acid:usefulness as a positive control for the in vitro evaluation of drug-drug interactions (2019). J. Pharm. Sci., 108(12), 3903-3910.
  3. Fujino C., Watanabe Y., Sanoh S., Nakajima H., Uramaru N., Kojima H., Yoshinari K., Ohta S., Kitamura S. Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver micorosmes (2019). Heliyon, 5(9), e02466. 　　
  4. Sanoh S., Tamura Y., Fujino C., Sugahara G., Yoshizane Y., Yanagi A., Kisoh K., Ishida Y., Tateno C., Ohta S., Kotake Y. Changes in bile acid concentrations after administration of ketoconazole or rifampicin to chimeric mice with humanized liver (2019). Biol. Pharm. Bull., 42(8), 1366-1375. 　　
  5. Fujino C., Sanoh S., Tamura Y., Ishida Y., Tateno C., Ohta S., Kotake Y.Changes in bile acid concentrations in chimeric mice transplanted with different replacement indexes of human hepatocytes (2019). BPB Reports., 2(2), 29-34.
  6. Fujino C., Sanoh S., Tateno C., Ohta S., Kotake Y. Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy (2019). Toxicol.Appl.Pharmacol., 370, 133-144. 　　
  7. Naritomi Y., Sanoh S., Ohta S. Utility of chimeric mice with humanized liver for predicting human pahrmacokinetics in drug discovery: Comparison with in vitro-in vivo extrapolation and allometric scaling (2019). Biol.Pharm.Bull.,42(3), 327-336. 　　
  8. Ohtsuki Y., Sanoh S., Santoh M., Ejiri Y., Ohta S., Kotake Y. Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives (2019). Biochem. Biophys. Res. Commun, 509(1), 287-293. 　　
  9. Kojima H., Takeuchi S., Sanoh S.,Okuda K.,Kitamura S.,Uramaru N.,Sugihara K., Yoshinari K. Profiling of bisphenol A and eight its analogue on transcriptional activity via human nuclear receptors (2019). Toxicology, 413, 48-55.

著書・その他

  • 古武 弥一郎「広島大学大学院医歯薬保健学研究科生体機能分子動態学研究室の紹介」ＨＡＢ研究機構ニュースレター, 25(2)

2018

学術論文

  1. 古武 弥一郎, 環境化学物質の神経毒性メカニズム解明およびその評価系構築に関する研究 (2018), 薬学雑誌, 138(10), 1227-1233.
  2. 佐能 正剛, 太田 茂, 創薬におけるヒト肝細胞キメラマウスを用いた薬効，毒性および薬物動態評価の有用性 (2018), 日本薬理学雑誌, 151(5), 213-220. 　　
  3. Takaoka N., Sanoh S., Okuda K., Kotake Y., Sugahara G., Yanagi A., Ishida Y., Tateno C., Tayama Y., Sugihara K., Kitamura S., Kurosaki M., Terao M., Garattini E., and Ohta S., Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions (2018) Biochem Pharmacol., 154, 28-38. 　　
  4. Yokoyama Y., Sasaki Y., Terasaki N., Kawataki T., Takekawa K., Iwase Y., Shimizu T., Sanoh S., and Ohta S., Comparison of drug metabolism and its related hepatotoxic effects in HepaRG, cryopreserved human hepatocytes, and HepG2 cell cultures (2018) Biol. Pharm. Bull., 41(5), 722-732. 　　
  5. Hanaoka S., Ishida K., Tanaka S., Sakamoto S., Okuda K., Sanoh S., Ohta S., and Kotake Y.(2018) Tributyltin induces epigenetic changes and decreases the expression of nuclear respiratory factor-1, Metallomics, 10, 337-345. 　　
  6. Naritomi, Y., Sanoh, S., and Ohta, S. (2018) Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery. Drug Metab. Pharmacokinet., 33, 31-39. 　　
  7. Umeda, K., Miyara, M., Ishida, K., Sanoh, S., Ohta, S., and Kotake, Y. (2018) Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons. Arch. Toxicol.,92, 401-409.

2017

学術論文

  1. Ishida, K., Aoki, K., Takishita, T., Miyara, M., Sakamoto, S., Sanoh, S., Kimura, T., Kanda, Y., Ohta, S., and Kotake, Y. (2017) Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1 Inhibition. Int. J. Mol. Sci.,18, pii:E1754.
  2. Ishida, K. , Kotake, Y. , Sanoh, S., and Ohta, S. (2017) Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons. Biol. Pharm. Bull.,40, 303-309.
  3. Ishida, K., Tsuyama, Y., Sanoh, S., Ohta, S., and Kotake, Y. (2017) Perfluorooctane sulfonate induces neuronal vulnerability by decreasing GluR2 expression. Arch. Toxicol., 91, 885-895.
  4. Ishida, K., Saiki, T., Umeda, K., Miyara, M., Sanoh, S., Ohta, S., and Kotake, Y. (2017) Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain. Biol. Pharm. Bull., 40, 1121-1124.
  5. Matsubara, K., Nakamura, N., Sanoh, S., Ohta, S., Kitamura, S., Uramaru, N., Miyagawa, S., Iguchi, T., and Fujimoto, N. (2017) Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption. J. Appl. Toxicol., 37, 1030-1035.
  6. Mori. J., Sanoh. S., Kashiwagi. K., Hanada. H., Shigeta. M., Suzuki. K.T., Yamamoto, T., Kotake, Y., Sugihara, K., Kitamura, S., Kashiwagi, A., and Ohta, S. (2017) Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis, J. Toxicol. Sci., 42, 605-613.
  7. Ozaki, H., Sugihara, K., Watanabe, Y., Moriguchi, K., Uramaru, N., Sone, T., Ohta, S., Kitamura, S. (2017) Comparative study of hydrolytic metabolism of dimethyl phthalate, dibutyl phthalate and di(2-ethylhexyl) phthalate by microsomes of various rat tissues. Food Chem. Toxicol., 100, 217-224.
  8. Sakamoto, S., Miyara, M., Sanoh, S., Ohta, S., and Kotake, Y. (2017) Mild MPP(+) exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation. Sci. Rep., 7, 46668.
  9. Sanoh, S., Yamachika, Y., Tamura, Y., Kotake, Y., Yoshizane, Y., Ishida, Y., Tateno, C., and Ohta, S. (2017) Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver, J Toxicol. Sci., 42, 589-596.
  10. Santoh, M., Sanoh, S., Ohtsuki, Y., Ejiri, Y., Kotake, Y., and Ohta, S. (2017) Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation. Biochem. Biophys. Res. Commun., 486, 639-644.
  11. Tanoue, C., Sugihara, K., Tayama, Y., Uramaru, N., Watanabe, Y., Ohta, S., and Kitamura, S. (2017) Variability of zaleplon 5-oxidase activity in mice and humans, and inhibition by raloxifene. Drug Metab. Lett., 10, 278-285.
  12. Yamada, T., Yamamoto, K., Ishihara, T., and Ohta, S. (2017) Purification of monoclonal antibodies entirely in flow-through mode. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.,1061-1062:110-116.