Graduate School of Biomedical and Health Sciences, Hiroshima University
Englishenglish
Overview
| Name | Department of Neurochemistry and Enviromental Health Sciences |
| Address | 1-2-3 Kasumi, Minamiku, Hiroshima-City, Japan, 734-8553 |
| Tel | 082-257-5327 |
Staffs
| Professor | Yaichiro KOTAKE (Ph.D) Speciality Field: Research of Low Molecular Toxin and Defense |
| Program-Specific Associate Professor | Ami OGURO(Ph.D) Speciality Field: Lipid Biochemistry , Molecular Biology |
| Assistant Professor | Masatsugu MIYARA (Ph.D) Speciality Field: Neurotoxicology , Cell Biology |
Messages from Prof. Kotake
Welcome to the homepage of the Department of Neurochemistry and Environmental
Health Sciences!
As a successor to Prof. Ohta, I have been in charge of the Laboratory of
the "Department of Neurochemistry and Environmental Health Sciences"
since April 2018, which belongs to the School of Pharmaceutical Sciences,
Hiroshima University. We examine the mechanisms underlying the toxicity
of chemicals in the environment, develop methods to screen chemicals, explore
toxicological makers, study the effects of the concentrations of environmental
chemicals and their involvement in the onset of Parkinson's disease, and
evaluate drug metabolism and the related toxicity of chemicals, including
pharmaceuticals. It is known that there are one-hundred million classfied
chemicals and that there are hundreds of thousands present in our surroundings.
However, the toxicities of the majority of these chemicals are still unclear,
and some of them could be hazarsous and cause various diseases.
Through these research projects as below, we will train pharmaceutical
researchers who think in a scientific manner. We hope to contribute to
the development of the next generation of human resources who can work
in a variety of fields as well as research.
Please contact us if you would like to join as a graduate student in our
research team.
Keywords of Research
Environmental chemicals, Tributyltin, Docosahexaenoic acid（DHA）, Epoxidehydrolase, Sensitivity of aroma, Parkinson's disease, MPTP (MPP+), Autophagy, Lysosome, Pharmaceutical, GluR2, Neurotoxicity, Toxicity assessment,Structure-activity relationship, PXB mouse, Pharmacokinetics, Metabolism, Aldehyde oxidase, CytochromeP450
Research Topic
(1) Elucidation of the neurotoxicity mechanism of chemicals in the environment and exploration of toxicological makers
(2) Elucidation of the physiological activity of unsaturated fatty acid metabolites in the brain
(3) Elucidation of the changes in sensitivity of aroma and indivisual differences
(Fusion oriented research for disruptive science and technology of 2021)
(4) Cellular biochemical studies of the toxic chemicals involved in thebonset of Parkinson's disease
(5) Drug metabolism, toxicity of chemicals, including pharmaceuticals, and their prediction in humans
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